Pseudoexfoliation Syndrome. This syndrome is characterized by the deposition of fibrillar material in the front of the eye, which can lead to an increase in eye pressure. Glaucoma associated with pseudoexfoliation syndrome can often lead to very high eye pressures. The lens may have poor support in patients with pseudoexfoliation, and cataract surgery can be more complex.
Pigmentary Glaucoma. Approximately 25 to 50% of those with pigment dispersion syndrome develop glaucoma. Risk factors include younger age, male sex, and myopia. Clinical findings include transillumination defects of the iris (the colored part of the eye), and pigment throughout the front part of the eye. Wide fluctuations in eye pressure are often seen; these are said to occur during period of pigment release during pupillary dilation or physical activity.
Drug-induced Glaucoma. In approximately one-third of patients, steroid use (in eye drops, eye injections, inhalers, creams, or pills) can lead to some elevation of eye pressure, especially if used for more than 3 weeks. This is more likely to happen in patients with glaucoma. Steroid related rise in eye pressure can occur at any point during treatment with the medication, so patients requiring chronic therapy with steroids need to be carefully monitored. Upon stopping steroids, steroid induced rise in eye pressure usually resolves within 2-4 weeks.