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FEATURED RESEARCH
Vibrational Optical
Coherence Tomography
Coherence Tomography
Vibrational optical coherence tomography (VOCT) is a novel approach that utilizes optical coherence tomography (OCT) to measure the resonant frequency (RF) of corneal components excited by a spectrum of audible sound frequencies. Through a calibration graph, RFs are converted to elastic moduli.
In this pilot study, we report the in vivo use of VOCT to determine the elastic moduli (stiffness) of the corneas of healthy human volunteers. This pilot study demonstrates the feasibility of utilizing VOCT to assess corneal RFs and elastic moduli. The noninvasive characteristic of the VOCT measurements makes it ideal for clinical applications. Future studies could employ VOCT to characterize corneal pathologies such as keratoconus to further assess the method’s utility in the clinical setting.
Crespo MA, Jimenez HJ, Deshmukh T, Pulido JS, Saad AS, Silver FH, Benedetto DA, Rapuano CJ, Syed ZA.
In Vivo Determination of the Human Corneal Elastic Modulus Using Vibrational Optical Coherence Tomography.
Transl Vis Sci Technol. 2022;11(7):11.
Meet Our Team
Jose Pulido, MD, MS, MPH, MBA
Larry A. Donoso Endowed Chair of Translational Ophthalmology
Dominick Benedetto, MD
Cataract & Refractive Surgeon
Kevin Hamill, MD
Senior Lecturer, Department of Eye and Vision Science, University of Liverpool
Felix Heide, PhD
Professor, Dept. of Computer Sciences Princeton University
Pearse Keane, MD
Professor of Artificial Medical Intelligence, UCL Institute of Ophthalmology
Omar Mahroo, MBBChir, PhD, FRCOphth
Professor of Retinal Neuroscience
UCL Institute of Ophthalmology,
Consultant, Moorfields Eye Hospital
UCL Institute of Ophthalmology,
Consultant, Moorfields Eye Hospital
Joseph Markoff, MD, PhD
Professor, Clinical Ophthalmology
Wills Eye Hospital and Thomas Jefferson University Hospitals
Wills Eye Hospital and Thomas Jefferson University Hospitals
Tatyana Milman, MD
Professor, Ophthalmology, Pathology, Anatomy and Cell Biology,
Wills Eye Hospital
Wills Eye Hospital
Rebecca Procopio, MS, CGS
Genetics Counselor,
Wills Eye Hospital
Wills Eye Hospital
Parsin Haji Reza, PhD
Research Chair in Biomedical Imaging, Department of Bioengineering, University of Waterloo
Zeba A. Syed, MD
Co-Director, Cornea Fellowship Program, Wills Eye Hospital
Email:
Adnan Tufail, MBBS,MD, FRCOphth
Professor, UCL Institute of Ophthalmology, Consultant Ophthalmologist, Moorefields Eye Hospital
Email:
Richard G. Vile, MD
Consultant, Department of Molecular Medicine, Professor of Immunology, May Clinic
Colin Willoughby, MD
Professor of Ophthalmology
Genomic Medicine
Ulster University
Genomic Medicine
Ulster University
Yongxin Zhao, MD
Eberly Family Associate Professor of Biological Sciences,
Carnegie Mellon University
Carnegie Mellon University