Fluorescein Angiography is a commonly used, office-based diagnostic test that can aid in determining the extent of macular degeneration and help distinguish between the dry and wet forms of the condition. Fluorescein angiography is performed by injecting sodium fluorescein dye into a peripheral vein with a small needle. This dye then goes through the blood vessels of the body and eyes. Choroidal neovasculation in the macula can be visualized as a leaking blood vessel complex under the retina. It is regarded as a safe test, but people should expect some yellowish skin discoloration and orange urine. Most people have no difficulty with this testing, although a low percentage of people will experience some nausea. Any angiogram test, however, can be associated with allergic or even more severe reactions, and therefore, this test is typically reserved for people in whom wet AMD is noted or suspected.