Intelligent Research in Sight
The nation’s first comprehensive eye disease clinical registry
The IRIS® Registry (Intelligent Research In Sight) is the nation’s first comprehensive eye disease clinical registry and one of the largest single specialty databases in the world. Users span all practice types, from solo practitioners to large institutions.
Established in 2014, the goals of the IRIS® Registry include :
• Creating both national and interpractice benchmark reports on best practices for improving patient care.
• Assisting practices with meeting federal reporting requirements.
• Enabling data analysis for population health, rare disease research, and new scientific discovery.
• Identifying safety signals in new drugs and devices.
“Prevalence of and Associated Factors for Eyelid Cancer in the American Academy of Ophthalmology Intelligent Research in Sight Registry” was accepted for publication in Ophthalmology Science. In this study, the authors evaluated the prevalence and associated factors of eyelid cancers in the American Academy of Ophthalmology Intelligent Research in Sight (IRIS) Registry. Using this large database of patient records, it was newly observed that smoking was associated with all types of eyelid tumors examined. This new finding in addition to the epidemiologic profile of eyelid cancers observed in this study will aid in identifying patients at risk for eyelid cancers and improving care.
Link to full publication: Baş Z, Sharpe J, Yaghy A, Zhang Q, Shields CL, Hyman L; IRIS Registry Analytic Center Consortium. Prevalence of and Associated Factors for Eyelid Cancer in the American Academy of Ophthalmology Intelligent Research in Sight Registry. Ophthalmol Sci. 2022 Sep 27;3(1):100227. doi: 10.1016/j.xops.2022.100227. PMID: 36439695; PMCID: PMC9692036. https://pubmed.ncbi.nlm.nih.gov/36439695/
Michael Morano MD won “Best Poster Award” for his poster – “Incidence and Risk Factors for Retinal Detachment and Retinal Tear after Cataract Surgery: IRIS® Registry Analysis” presented at 2022 American Academy of Ophthalmology Annual Meeting which examined the incidence and risk factors of a retinal tear (RT) or rhegmatogenous retinal detachment(RRD) within a year after cataract surgery
Prevalence and Associated Factors for Thyroid Eye Disease
Thyroid Eye Disease (TED) is a rare, potentially debilitating and disfiguring eye condition. The prevalence of TED and its associated factors in the IRIS Registry are being examined in this large patient population.
Demographic disparities in Anti-Vascular Endothelial Growth Factor Therapy (VEGF) for Retinal Vein Occlusion (RVO)
Retinal Vein Occlusion (RVO) is one of the most common causes of retinal vascular diseases and risk factors include high blood pressure, vascular diseases and diabetes. The aim of this study is to investigate possible disparities between demographic groups in initiation of treatment with anti-VEGF injections and clinical outcomes for patients with RVO in the IRIS Registry.
Retinal Complications from Cataract Surgery
Cataract surgery is one of the most commonly performed surgical procedures in the United States and while cataract surgery is safe and effective in improving vision and visual functioning, post-surgical complications may occur. This study is using the data in the IRIS Registry to estimate the frequency of retinal complications within one year post cataract surgery, evaluate demographic and ocular risk factors for retinal events post cataract surgery, and compare differences in rates of retinal events among uncomplicated and complicated cataract procedures.
The IRS Registry Analytic Center Consortium is comprised of 4 institutions, Massachusetts Eye and Ear/Harvard Ophthalmology, Stanford University, University of Washington, and Wills Eye Hospital, in collaboration with the American Academy of Ophthalmology. The IRIS Registry Analytic Center Consortium has full access to the IRIS Registry and works together to advance knowledge in ophthalmology through studies using real world clinical data.
Massachusetts Eye & Ear
University of Washington