Diabetic Retinopathy - PDR

There are two major types of diabetic retinopathy: non-proliferative retinopathy and proliferative retinopathy. Non-proliferative diabetic retinopathy is the earlier stage and is characterized by visible damage to small retinal blood vessels. These blood vessels may develop balloon-like swelling called microaneurysms. Microaneurysms and other areas of abnormal retinal blood vessels may leak fluid, causing the retina to swell or bleed. This may lead to vision loss. Leakage in the center of the retina (macula), known as macular edema, is the most common mechanism of vision loss in people with diabetic retinopathy. Non-proliferative diabetic retinopathy is the most common form of diabetic retinopathy, accounting for approximately 80% of all cases.

Some people progress to the more advanced proliferative diabetic retinopathy stage. Proliferative diabetic retinopathy is characterized by such severe small retinal vessel damage and reduced oxygenization of the retina that the retina reacts by growing abnormal blood vessels (neovascularization). These abnormal blood vessels are fragile and can bleed and pull on the retina as they grow. Bleeding into the vitreous cavity of the eye (vitreous hemorrhage) can result in sudden and sometimes severe loss of vision. This type of hemorrhage is painless and, early on, may be seen as cobweb-like floaters in one’s vision. New floaters and any sudden vision change in a person with diabetic retinopathy should be evaluated promptly by an ophthalmologist.

Proliferative diabetic retinopathy can also lead to traction retinal detachments. The retinal neovascularization can grow to be large and then contract, pull, and lift the retina. Retinal detachment can lead to loss of vision if it involves the macula.