Salzmann’s Nodular Degeneration

Definition

Creamy white elevated corneal nodules, most commonly peripherally, but can also occur centrally.

Symptoms

Often asymptomatic but can cause mild foreign body sensation and mild to severe decreased vision.

Causes

Unknown.

Risk Factors

Female gender, possibly prior corneal trauma or contact lens wear.

Complications

Corneal scarring and vascularization.

Tests and Diagnosis

Slit lamp examination is essential. Corneal topography can often detect irregular astigmatism caused by the nodules 8. Treatment: Lubrication if mild. Surgical excision with a blade or excimer laser PTK when more severe or causing significant symptoms. Application of mitomycin C at the time of surgical excision may decrease the risk of recurrence.

Prevention

Perhaps sunglasses to limit ultraviolet exposure.